From: Immunosenescence, inflammation and Alzheimer’s disease
T cells and B cells or B-cell products | Lymphocyte subpopulations | Change | Reference |
---|---|---|---|
CD3+, CD3+CD4+, CD3+CD8+ | Total T cells, T helper cells, | Decrease | [9] |
(percentage and absolute number) | cytotoxic T lymphocytes | [14] | |
CD3+CD45RA+CD62L+ | Naïve T cells | Decrease | [10] |
(percentage) | [11] | ||
[12] | |||
[13] | |||
CD8+CD28- | Effector T cells | Increase | [10] |
(percentage) | [11] | ||
[12] | |||
[13] | |||
CD19+ | Total B cells | Decrease | [24] |
(percentage and absolute number) | [25] | ||
[16] | |||
[17] | |||
[18] | |||
CD19+CD5+ | B1 cells | Decrease | [15] |
(percentage and absolute number) | |||
CD19+IgD+CD27– | Naïve B cells | Decrease | [19] |
(percentage) | |||
CD19+IgD-CD27– | Double Negative B cells | Increase | [19] |
(percentage) | [24] | ||
[20] | |||
IgG, IgA | Increase | [21] | |
No change | [22] | ||
IgD, IgM | Decrease | [21] | |
IgE | No change | [21] | |
(after specific immunization) | [22] | ||
Decrease | [23] | ||
Autoantibodies | Increase | [27] | |
[26] |