Caffeine delays age-associated paralysis in a worm polyglutamine toxicity model. Caffeine treatment delayed the onset of paralysis in worms expressing Q35::YFP in their body wall muscles at (A) 15°C, (B) 20°C, and (C) 25°C. (D) Caffeine reduced the formation of Q35::YFP aggregates at 15°C. Error bars represent standard error. *P < 0.05 vs. 0 mM.