Figure 7From: Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegansCaffeine displays epistatic interaction with IIS components. 5 mM or 10 mM caffeine extends life span in wild-type (A), but not daf-16(mu86) (B), worms, and in wild-type worms fed EV(RNAi) (C), but not worms fed daf-16(RNAi) (D) or daf-2(RNAi) ( E ).Back to article page