Performance on memory tasks after 16 months of treatment. (A) Latency to find the platform during the acquisition phase of the Morris water mazetest (means ± S.E.M.) and (B) time spent in the target quadrant during the probe task (means ± S.E.M.). (C) Inhibitory avoidance task latency to step down onto the platform (median/interquartile ranges) during training and at the short- and long-term memory tests. Controldiet(n = 12) and high fat diet groups (diet-induced obese (DIO), n = 7; diet resistant (DR), n = 6). *P< 0.05, test sections > training section.