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Figure 7 | Longevity & Healthspan

Figure 7

From: Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage

Figure 7

Markers of oxidative stress in control versus low GI mice. (A) Abasic DNA sites were identified in both control mice and the low GI group mice at each time interval and data shown are number of abasic sites per 100,000 base pairs (bp) (n = 16 for 6- to 20-month-old animals, n = 8 for 24-month-old animals); * indicates significant difference between 20-month-old control versus 24-month-old control, ** indicates significant difference between 24-month-old control versus 24-month low GI (P <0.05); solid line () denotes control, perforated line (- - -) denotes low GI. (B) Levels of 8-OH-2dG formation in DNA in both control mice and low GI mice at each time interval, data shown are pg/mL of 8-OH-2dG formed (n = 16 for 6- to 20-month-old animals, n = 8 for 24-month-old animals); * indicates significant difference between 20-month-old control versus 24-month-old control, ** indicates significant difference between 24-month-old control versus 24-month low GI (P <0.05); solid line () denotes control, perforated line (- - -) denotes low GI.

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