Lifespan extension in sft-1(RNAi) and oxa-1(RNAi) animals. A: Lifespan curves for N2, oxa-1(RNAi) and sft-1(RNAi) animals (recorded as number of days of survival post L4, or the time at which controls reached L4, in the case of oxa-1(RNAi) animals). Lifespan is prolonged in sft-1(RNAi) and oxa-1(RNAi) animals compared with WT controls, with oxa-1 having the greatest effect. B: Lifespan analysis of sft-1(RNAi) animals performed in a daf-16(m26) mutant background, in which sft-1 RNAi fails to extend lifespan. C: Lifespan analysis of oxa-1(RNAi) animals performed in a daf-16(m26) mutant background. oxa-1 RNAi still extends lifespan under these circumstances. The data presented combine three independent data sets (the data for individual replicate experiments can be found in Additional file 1).