From: A midlife crisis for the mitochondrial free radical theory of aging
Species investigated | Tissue | Metabolic substrate(s) used | Relationship to MLSP* | Reference |
---|---|---|---|---|
Fruit fly Drosophila melanogaster | Whole body | Pyruvate + proline | Weak correlation | [23] |
Glycerol-3-phosphate | Weak correlation males only | |||
Glycerol-3-phosphate + rotenone | ||||
No correlation | ||||
Naked mole rat Heterocephalus glaber, Damara mole rat Cryptomas damarensis, Guinea pig Cavia porcellus, laboratory mouse Mus musculus | Vascular tissue | Succinate ± rotenone | No correlation | [24] |
Domestic pigeon Columba livia, Japanese quail Coturnix japonica, laboratory rat Rattus norvegicus | Isolated heart mitochondria | Succinate | Negative correlation | [25] |
Succinate + rotenone | No correlation | |||
Laboratory mouse Mus musculus, house sparrow Passer domesticus | Isolated liver mitochondria | Glutamate + malate | No correlation when standardized to total O2 consumption | [26] |
Laboratory mouse Mus musculus, house sparrow Passer domesticus | Isolated mitochondria from pectoralis (sparrow) or hindlimb (rat) muscle | Multiple substrates | No correlation when O2 consumption rates considered | [28] |
Pigeon (species not indicated), rat (Rattus norvegicus) | Isolated mitochondria from heart, muscle and liver | Pyruvate + malate | Higher rates in pigeon muscle | [27] |
Succinate | ||||
Higher rates in rat heart | ||||
Succinate + rotenone | ||||
Higher rates in rat heart | ||||
Little brown bat Myotis lucifugus, short-tailed shrew Blarina brevicauda, white-footed mouse Peromyscus leucopus | Isolated mitochondria from brain, heart, kidney | Not given | No correlation | [29] |
Little brown bat Myotis lucifugus, laboratory mouse Mus musculus | Isolated liver mitochondria | Glutamate + malate | Negative correlation | [26] |
12 mammalian and avian species | Isolated heart mitochondria | Succinate | Negative correlation | [25] |
Succinate + rotenone | ||||
No correlation | ||||
No correlation | ||||
 |  | Pyruvate + malate ± rotentone |  |  |