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Table 1 Hydrogen peroxide production by isolated mitochondria or tissue of relatively short- and long-lived animal species

From: A midlife crisis for the mitochondrial free radical theory of aging

Species investigated

Tissue

Metabolic substrate(s) used

Relationship to MLSP*

Reference

Fruit fly Drosophila melanogaster

Whole body

Pyruvate + proline

Weak correlation

[23]

Glycerol-3-phosphate

Weak correlation males only

Glycerol-3-phosphate + rotenone

No correlation

Naked mole rat Heterocephalus glaber, Damara mole rat Cryptomas damarensis, Guinea pig Cavia porcellus, laboratory mouse Mus musculus

Vascular tissue

Succinate ± rotenone

No correlation

[24]

Domestic pigeon Columba livia, Japanese quail Coturnix japonica, laboratory rat Rattus norvegicus

Isolated heart mitochondria

Succinate

Negative correlation

[25]

Succinate + rotenone

No correlation

Laboratory mouse Mus musculus, house sparrow Passer domesticus

Isolated liver mitochondria

Glutamate + malate

No correlation when standardized to total O2 consumption

[26]

Laboratory mouse Mus musculus, house sparrow Passer domesticus

Isolated mitochondria from pectoralis (sparrow) or hindlimb (rat) muscle

Multiple substrates

No correlation when O2 consumption rates considered

[28]

Pigeon (species not indicated), rat (Rattus norvegicus)

Isolated mitochondria from heart, muscle and liver

Pyruvate + malate

Higher rates in pigeon muscle

[27]

Succinate

Higher rates in rat heart

Succinate + rotenone

Higher rates in rat heart

Little brown bat Myotis lucifugus, short-tailed shrew Blarina brevicauda, white-footed mouse Peromyscus leucopus

Isolated mitochondria from brain, heart, kidney

Not given

No correlation

[29]

Little brown bat Myotis lucifugus, laboratory mouse Mus musculus

Isolated liver mitochondria

Glutamate + malate

Negative correlation

[26]

12 mammalian and avian species

Isolated heart mitochondria

Succinate

Negative correlation

[25]

Succinate + rotenone

No correlation

No correlation

  

Pyruvate + malate ± rotentone

  
  1. *MLSP = Maximum Lifespan.