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Table 1 Hydrogen peroxide production by isolated mitochondria or tissue of relatively short- and long-lived animal species

From: A midlife crisis for the mitochondrial free radical theory of aging

Species investigated Tissue Metabolic substrate(s) used Relationship to MLSP* Reference
Fruit fly Drosophila melanogaster Whole body Pyruvate + proline Weak correlation [23]
Glycerol-3-phosphate Weak correlation males only
Glycerol-3-phosphate + rotenone
No correlation
Naked mole rat Heterocephalus glaber, Damara mole rat Cryptomas damarensis, Guinea pig Cavia porcellus, laboratory mouse Mus musculus Vascular tissue Succinate ± rotenone No correlation [24]
Domestic pigeon Columba livia, Japanese quail Coturnix japonica, laboratory rat Rattus norvegicus Isolated heart mitochondria Succinate Negative correlation [25]
Succinate + rotenone No correlation
Laboratory mouse Mus musculus, house sparrow Passer domesticus Isolated liver mitochondria Glutamate + malate No correlation when standardized to total O2 consumption [26]
Laboratory mouse Mus musculus, house sparrow Passer domesticus Isolated mitochondria from pectoralis (sparrow) or hindlimb (rat) muscle Multiple substrates No correlation when O2 consumption rates considered [28]
Pigeon (species not indicated), rat (Rattus norvegicus) Isolated mitochondria from heart, muscle and liver Pyruvate + malate Higher rates in pigeon muscle [27]
Succinate
Higher rates in rat heart
Succinate + rotenone
Higher rates in rat heart
Little brown bat Myotis lucifugus, short-tailed shrew Blarina brevicauda, white-footed mouse Peromyscus leucopus Isolated mitochondria from brain, heart, kidney Not given No correlation [29]
Little brown bat Myotis lucifugus, laboratory mouse Mus musculus Isolated liver mitochondria Glutamate + malate Negative correlation [26]
12 mammalian and avian species Isolated heart mitochondria Succinate Negative correlation [25]
Succinate + rotenone
No correlation
No correlation
   Pyruvate + malate ± rotentone   
  1. *MLSP = Maximum Lifespan.