Table 2 Survival data for mice over-expressing or under-expressing antioxidant enzymes

Single gene manipulations:

Mn superoxide dismutase

Sod2 Tg

C57BL/6 (males)

50

1,165 d (1,092 to 1,245) [versus 1,128 d (1,080 to 1,206)]

No

[49]

Sod2 Tg

Not indicated

24

N/A - 43.0 months [versus 36.5 months] and

N/A*

[52]

Sod2 ^+/−

C57BL/6 (females)

70

1,027 d (1,044 to 1,154) [versus 1,034 d (1,002 to 1,099)]

No

[53]

CuZn superoxide dismutase

Sod1 Tg

C57BL/6 (male)

44

1,121 d [versus 1,090 d]

No

[50]

Sod1 Tg (homozygous)

CD1

119

30 months [versus 31 months]^!

No

[54]

Sod1 Tg (hemizygous)

CD1

200

31 months [versus 31 months]^!

No

[54]

Sod1 ^−/−

C57BL/6

10

762 d (761 to 767) [versus 1,076 d (1,035 to 1,298)]

Yes - decrease in mean lifespan

[51]

Sod1 ^+/−

C57BL/6

12

N/A - 28.7 ± 1.3 months [versus 29.8 ± 2.1 months]^{^}

No

[55]

Sod1 ^−/−

C57BL/6

18

N/A - 20.8 ± 0.7 months [versus 29.8 ± 2.1 months^C1]^{^}

Yes

[55]

Catalase

Cat Tg

C57BL/6 (male)

44

1,099 d [versus 1,090 d]

No

[50]

Cat Tg ^p

C57BL/6 ^<

44

N/A (only a survivor curve was given - clear values not provided)

No’

[56]

Cat Tg ^m

C57BL/6 ^<

62

N/A

Yes - increased median and maximum lifespan

[56]

Cat Tg ⁿ

C57BL/6 ^<

78

N/A

No

[56]

Glutathione peroxidase 4

Gpx4 Tg

C57BL/6 (males)

18

1,072 d (1,062 to 1,080) [versus 1,106 d (1,026 to 1,161)]

No

[51]

Gpx4 ^+/−

C57BL/6 (females)

50

1,126 ± 20 d [versus 1,145 ± 9 d]

Yes - significant increase in mean lifespan only

[57]

Glutathione peroxidase 1

Gpx1 ^−/−

C57BL/6 (females)

59

1,063 d (1,031 to 1,183) [versus 1,091 d (1,040 to 1,188)]

No

[58]

Thioredoxin 1

Trx1 Tg

C57BL/6 (males)^>

41

1,134 d [versus 1,159 d]

No^#

[59]

Trx1 Tg

C57BL/6 (males)^>

60

1,151 d [versus 1,143 d]

No^#

[59]

Trx1 Tg

C57BL/6 (females)

40

1,152 d [versus 1,230 d]

No

[59]

Thioredoxin 2

Trx2 ^+/−

Mix of C57BL/6 J & 129 (females)

26

1,059 d (1,020 to 1,139) [versus 1,186 d (1,086 to 1,359)]

No

[51]

Methionine sulfoxide reductase

MsrA ^−/−

Mix of C57BL/6 J & 129 (males)

25

1,157 d (1,105 to 1,203) [versus 1,140 d (1,092 to 1,204)]^C2

No

[60]

MsrA ^−/−

C57BL/6 J

17

N/A - 409 ± 33 d [versus 680 ± 71 d]^{^}

Yes - increase in mean lifespan

[61]

MsrA ^+/−

C57BL/6 J

8

N/A - 672 ± 80 d [versus 680 ± 71 d]^{^}

No

[61]

Multiple gene manipulations:

Sod1 Tg / Sod2 Tg

C57BL/6 (males)

54

1,075 d [versus 1,090 d]

No

[50]

S od1 ^−/− / S od2 ^+/−

C57BL/6

11

886 d (817 to 883) [versus 1,076 d (1,035 to 1,298)]

Yes

[51]

Sod1 Tg / Cat Tg

C57BL/6 (males)

47

1,098 d [versus 1,090 d]

No

[50]

Sod2 ^+/− / Gpx4 ^+/−

C57BL/6

11

1,025 d (938 to 1,099) [versus 1,076 d (1,035 to 1,298)]

No

[51]

Sod2 ^+/− / Gpx1 ^+/−

C57BL/6

25

1,057 d (1,027 to 1,298) [versus 1,091 d (1,040 to 1,188)]

No

[58]

Sod2 ^+/− /Gpx1 ^−/−

C57BL/6

33

1,121 d (1,069 to 1,248) [versus 1,091 d (1,040 to 1,188)]

No

[58]

Sod1 ^−/− / Gpx1 ^−/−

C57BL/6 (males)

11

828 d (799 to 868) [versus 1,076 d (1,035 to 1,298)]

Yes - decrease in mean lifespan

[51]

Sod1 ^−/− / Gpx4 ^+/−

C57BL/6 (males)

16

866 d (817 to 883 [versus 1,076 d (1,035 to 1,298)]

Yes - decrease in mean and median lifespan

[51]

Gpx1 ^-/ / Gpx4 ^+/−

C57BL/6

40

1,124 d (1,086 to 1,359) [versus 1,076 d (1,035 to 1,298)]

No

[51]