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Figure 7 | Longevity & Healthspan

Figure 7

From: The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators

Figure 7

Regulation of S100A7 (psoriasin) and S100A15 (koebnerisin) by TRF2ΔBΔM, the senescence effectors and IR. S100A7 and S100A15 gene expression levels (a) in keratinocytes transduced with p14ARF, p16INK4A, p53 and TRF2ΔBΔM, reported as a fold change in transcript relative to the respective empty vector control; data are represented per NHEK population corresponding to LOW or MEDIUM/HIGH expression of the transgenes. (b) Keratinocytes irradiated with 2 gray (low dose IR) and (c) 10 or 20 gray (high doses IR), reported as a fold change in transcript relative to the non-irradiated control (0 gray); data are mean ± sd from three independent measurements (n =3). Legend: EV, empty vector; p14ARF, NHEK expressing pBabe-p14ARF; p16INK4a, NHEK expressing pBabe-p16INK4a; p53, NHEK expressing pBabe-p53; TRF2DN, NHEK expressing pLPC-TRF2ΔBΔM.

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