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Longevity & Healthspan

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  1. Content type: Research

    The longevity of an organism is influenced by both genetic and environmental factors. With respect to genetic factors, a significant effort is being made to identify pharmacological agents that extend life spa...

    Authors: George L Sutphin, Emma Bishop, Melana E Yanos, Richard M Moller and Matt Kaeberlein

    Citation: Longevity & Healthspan 2012 1:9

    Published on:

  2. Content type: Review

    Ageing impacts negatively on the development of the immune system and its ability to fight pathogens. Progressive changes in the T-cell and B-cell systems over the lifespan of individuals have a major impact o...

    Authors: Adriana Martorana, Matteo Bulati, Silvio Buffa, Mariavaleria Pellicanò, Calogero Caruso, Giuseppina Candore and Giuseppina Colonna-Romano

    Citation: Longevity & Healthspan 2012 1:8

    Published on:

  3. Content type: Review

    The decreased efficiency of immune responses in older people is partly a consequence of alterations in T lymphocyte functions caused by modifications in the early events of signal transduction. Several alterat...

    Authors: Tamas Fulop, Aurélie Le Page, Hugo Garneau, Naheed Azimi, Sarra Baehl, Gilles Dupuis, Graham Pawelec and Anis Larbi

    Citation: Longevity & Healthspan 2012 1:6

    Published on:

  4. Content type: Meeting report

    An international workshop was hosted by the University of Liverpool on 15–16 July 2011 to address at a basic level what is known about the fundamental mechanisms by which skeletal muscle mass and function are ...

    Authors: Malcolm J Jackson, Anne McArdle, Aphrodite Vasilaki and Anna Kayani

    Citation: Longevity & Healthspan 2012 1:5

    Published on:

  5. Content type: Review

    The Free Radical or Oxidative Stress Theory of Aging is one of the most popular theories in aging research and has been extensively studied over the past several decades. However, recent evidence using transge...

    Authors: Lisa C Flores, Melanie Ortiz, Sara Dube, Gene B Hubbard, Shuko Lee, Adam Salmon, Yiqiang Zhang and Yuji Ikeno

    Citation: Longevity & Healthspan 2012 1:4

    Published on:

  6. Content type: Research

    Chronic dietary restriction (DR) has been shown to have beneficial effects on glucose homeostasis and insulin sensitivity. These factors show rapid and robust improvements when rodents were crossed over from an a...

    Authors: Kerry M Cameron, Satomi Miwa, Cornelia Walker and Thomas von Zglinicki

    Citation: Longevity & Healthspan 2012 1:3

    Published on:

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