Table 2 Main modifications of lymphocytes subpopulations between Alzheimer’s disease patients and age-matched controls
From: Immunosenescence, inflammation and Alzheimer’s disease
Phenotype | Lymphocyte subpopulation | Changesin Alzheimer disease | Reference |
|---|---|---|---|
CD19+ | Total B cells | Decrease | [82] |
(percentage) | [83] | ||
[63] | |||
CD19+ | Total B cells | Decrease | [82] |
(absolute number) | [63] | ||
CD3+ | Total T cells | No change | [63] |
(percentage) | Decrease | [81] | |
[83] | |||
CD3+CD8+(percentage) | Cytotoxic T lymphocytes | No change | [63] |
[83] | |||
Decrease | [81] | ||
CD3+CD4+ | T-helper cells | No change | [63] |
(percentage) | [83] | ||
Increase | [81] | ||
CD3+CD4+CD45RA+CCR7+ | Naïve CD4+ T | Decrease | [79] |
(percentage) | cells | ||
CD3+CD4+CD28+CD27+CD45RA+CD45RO- | Naïve CD4+ T | Decrease | [75] |
(percentage) | cells | ||
CD3+CD4+CD45RA-CCR7- | Effector memory | Increase | [79] |
(percentage) | CD4+ T cells | ||
CD3+CD4+CD45RA+CCR7-(percentage) | Terminal effector memory RA cells | Increase | [79] |
CD3+CD4+CD28-CD27-CD45RA+CD45RO+ | Late differentiated | Increase | [75] |
(percentage) | CD4+ T cells | ||
CD3+CD4+CD25high | Activated CD4+ T | Decrease | [79] |
(percentage) | cells | ||
CD3+CD4+CD25+FoxP3+CD127low(percentage) | Regulatory T cells | No change | [75] |
CD3+CD4+KLRG-1+(percentage) | Senescent CD4+ T cells | Increase | [75] |