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Table 2 Main modifications of lymphocytes subpopulations between Alzheimer’s disease patients and age-matched controls

From: Immunosenescence, inflammation and Alzheimer’s disease

Phenotype Lymphocyte subpopulation Changesin Alzheimer disease Reference
CD19+ Total B cells Decrease [82]
(percentage)    [83]
    [63]
CD19+ Total B cells Decrease [82]
(absolute number)    [63]
CD3+ Total T cells No change [63]
(percentage)   Decrease [81]
    [83]
CD3+CD8+(percentage) Cytotoxic T lymphocytes No change [63]
    [83]
   Decrease [81]
CD3+CD4+ T-helper cells No change [63]
(percentage)    [83]
   Increase [81]
CD3+CD4+CD45RA+CCR7+ Naïve CD4+ T Decrease [79]
(percentage) cells   
CD3+CD4+CD28+CD27+CD45RA+CD45RO- Naïve CD4+ T Decrease [75]
(percentage) cells   
CD3+CD4+CD45RA-CCR7- Effector memory Increase [79]
(percentage) CD4+ T cells   
CD3+CD4+CD45RA+CCR7-(percentage) Terminal effector memory RA cells Increase [79]
CD3+CD4+CD28-CD27-CD45RA+CD45RO+ Late differentiated Increase [75]
(percentage) CD4+ T cells   
CD3+CD4+CD25high Activated CD4+ T Decrease [79]
(percentage) cells   
CD3+CD4+CD25+FoxP3+CD127low(percentage) Regulatory T cells No change [75]
CD3+CD4+KLRG-1+(percentage) Senescent CD4+ T cells Increase [75]