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  1. Research

    Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice

    Extending mammalian health span and life span has been achieved under a variety of dietary restriction protocols. Reducing the intake of a specific amino acid has also been shown to extend health and longevity...

    Holly M Brown-Borg, Sharlene Rakoczy, Joseph A Wonderlich, Vanessa Armstrong and Lalida Rojanathammanee

    Longevity & Healthspan 2014 3:10

    Published on: 15 December 2014

  2. Review

    It is not just muscle mass: a review of muscle quality, composition and metabolism during ageing as determinants of muscle function and mobility in later life

    Worldwide estimates predict 2 billion people will be aged over 65 years by 2050. A major current challenge is maintaining mobility and quality of life into old age. Impaired mobility is often a precursor of fu...

    Robin A McGregor, David Cameron-Smith and Sally D Poppitt

    Longevity & Healthspan 2014 3:9

    Published on: 1 December 2014

  3. Research

    The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators

    Replicative senescence is preceded by loss of repeat sequences of DNA from the telomeres that eventually leads to telomere dysfunction, the accumulation of irreparable DNA double strand breaks and a DNA damage...

    Alice de Castro, Fay Minty, Eva Hattinger, Ronald Wolf and Eric Kenneth Parkinson

    Longevity & Healthspan 2014 3:8

    Published on: 17 October 2014

  4. Editorial

    The role of mitochondria in longevity and healthspan

    The role of mitochondria in aging and disease remains contentious more than 40 years after the mitochondrial free radical theory of aging was first proposed. As part of a wider cross-journal series on contempo...

    Martin D Brand

    Longevity & Healthspan 2014 3:7

    Published on: 22 May 2014

  5. Review

    Mitochondrial oxidative stress in aging and healthspan

    The free radical theory of aging proposes that reactive oxygen species (ROS)-induced accumulation of damage to cellular macromolecules is a primary driving force of aging and a major determinant of lifespan. A...

    Dao-Fu Dai, Ying Ann Chiao, David J Marcinek, Hazel H Szeto and Peter S Rabinovitch

    Longevity & Healthspan 2014 3:6

    Published on: 1 May 2014

  6. Research

    Transcriptional regulation of Caenorhabditis elegansFOXO/DAF-16 modulates lifespan

    Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of insulin/IGF-1 signaling, and multiple is...

    Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr, Haibo Liu, Michael J Gilchrist, Lesley T MacNeil and Heidi A Tissenbaum

    Longevity & Healthspan 2014 3:5

    Published on: 23 April 2014

  7. Review

    A midlife crisis for the mitochondrial free radical theory of aging

    Since its inception more than four decades ago, the Mitochondrial Free Radical Theory of Aging (MFRTA) has served as a touchstone for research into the biology of aging. The MFRTA suggests that oxidative damag...

    Jeffrey A Stuart, Lucas A Maddalena, Max Merilovich and Ellen L Robb

    Longevity & Healthspan 2014 3:4

    Published on: 1 April 2014

  8. Review

    Mitochondrial and sex steroid hormone crosstalk during aging

    Decline in circulating sex steroid hormones accompanies several age-associated pathologies which may influence human healthspan. Mitochondria play important roles in biosynthesis of sex steroid hormones, and t...

    Michael C Velarde

    Longevity & Healthspan 2014 3:2

    Published on: 5 February 2014

  9. Research

    Evidence of changes to skeletal muscle contractile properties during the initiation of disease in the ageing guinea pig model of osteoarthritis

    Osteoarthritis (OA) is the most common joint disorder in the world and represents the leading cause of pain and disability in the elderly population. Advancing age remains the single greatest risk factor for O...

    Daniel P Tonge, Ronald G Bardsley, Tim Parr, Rose A Maciewicz and Simon W Jones

    Longevity & Healthspan 2013 2:15

    Published on: 1 December 2013

  10. Research

    Life-long spontaneous exercise does not prolong lifespan but improves health span in mice

    Life expectancy at birth in the first world has increased from 35 years at the beginning of the 20th century to more than 80 years now. The increase in life expectancy has resulted in an increase in age-relate...

    Rebeca Garcia-Valles, Mari Carmen Gomez-Cabrera, Leocadio Rodriguez-Mañas, Francisco J Garcia-Garcia, Ana Diaz, Inma Noguera, Gloria Olaso-Gonzalez and Jose Viña

    Longevity & Healthspan 2013 2:14

    Published on: 16 September 2013

  11. Review

    Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses

    Aging-related loss of muscle mass, a biological process named sarcopenia, contributes to mobility impairment, falls, and physical frailty, resulting in an impaired quality of life in older people. In view of t...

    Gilles Gouspillou, Martin Picard, Richard Godin, Yan Burelle and Russell T Hepple

    Longevity & Healthspan 2013 2:13

    Published on: 1 August 2013

  12. Research

    Lifelong endurance training attenuates age-related genotoxic stress in human skeletal muscle

    The aim of the present study was to determine the influence of age and habitual activity level, at rest and following a single bout of high-intensity exercise, on the levels of three proteins poly(ADP-ribose) ...

    James N Cobley, George K Sakellariou, Scott Murray, Sarah Waldron, Warren Gregson, Jatin G Burniston, James P Morton, Lesley A Iwanejko and Graeme L Close

    Longevity & Healthspan 2013 2:11

    Published on: 12 July 2013

  13. Short Report

    High saturated fat and low carbohydrate diet decreases lifespan independent of body weight in mice

    Obesity is a health problem that is reaching epidemic proportions worldwide. We investigated the effects of a life-long high saturated fat and low carbohydrate (HF) diet on the body mass, glucose tolerance, co...

    Alexandre Pastoris Muller, Marcelo de Oliveira Dietrich, Adriano Martimbianco de Assis, Diogo Onofre Souza and Luis Valmor Portela

    Longevity & Healthspan 2013 2:10

    Published on: 3 June 2013

  14. Research

    The SFT-1 and OXA-1 respiratory chain complex assembly factors influence lifespan by distinct mechanisms in C. elegans

    C. elegans mitochondrial (Mit) mutants have disrupted mitochondrial electron transport chain function, yet, surprisingly, they are often long-lived, a property that has offered unique insights into the molecular ...

    Sara Maxwell, Joanne Harding, Charles Brabin, Peter J Appleford, Ruth Brown, Carol Delaney, Garry Brown and Alison Woollard

    Longevity & Healthspan 2013 2:9

    Published on: 8 May 2013

  15. Review

    Understanding how we age: insights into inflammaging

    Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.

    Daniel Baylis, David B Bartlett, Harnish P Patel and Helen C Roberts

    Longevity & Healthspan 2013 2:8

    Published on: 2 May 2013

  16. Research

    Lifespan extension and delay of age-related functional decline caused by Rhodiola roseadepends on dietary macronutrient balance

    This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit...

    Dmytro V Gospodaryov, Ihor S Yurkevych, Mahtab Jafari, Volodymyr I Lushchak and Oleh V Lushchak

    Longevity & Healthspan 2013 2:5

    Published on: 2 April 2013

    The Erratum to this article has been published in Longevity & Healthspan 2013 2:12

  17. Research

    Consumption of a low glycaemic index diet in late life extends lifespan of Balb/c mice with differential effects on DNA damage

    Caloric restriction is known to extend the lifespan of all organisms in which it has been tested. Consequently, current research is investigating the role of various foods to improve health and lifespan. The r...

    Scott A Nankervis, Jenee M Mitchell, Fadi J Charchar, Maree A McGlynn and Paul A Lewandowski

    Longevity & Healthspan 2013 2:4

    Published on: 1 March 2013

  18. Review

    Systems integrity in health and aging - an animal model approach

    Human lifespan is positively correlated with childhood intelligence, as measured by psychometric (IQ) tests. The strength of this correlation is similar to the negative effect that smoking has on the life cour...

    Marije Oostindjer and Gro V Amdam

    Longevity & Healthspan 2013 2:2

    Published on: 7 January 2013

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