Figure 4
From: Accumulation of prelamin A compromises NF-κB-regulated B-lymphopoiesis in a progeria mouse model
Defective NF-κB signaling in Zmpste24−/−bone marrow stromal cells. (A) Representative western blotting results showing that upon transient TNFα stimulation, NF-κB was defective in activating IκBα/β expression and the following negative feedback in Zmpste24−/− bone marrow stromal cells (BMSCs). (B) Quantification of p65 and IκBα/β after TNFα treatment in (A) by Image J (see Materials and Methods)