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  1. Content type: Research

    Extending mammalian health span and life span has been achieved under a variety of dietary restriction protocols. Reducing the intake of a specific amino acid has also been shown to extend health and longevity...

    Authors: Holly M Brown-Borg, Sharlene Rakoczy, Joseph A Wonderlich, Vanessa Armstrong and Lalida Rojanathammanee

    Citation: Longevity & Healthspan 2014 3:10

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  2. Content type: Review

    Worldwide estimates predict 2 billion people will be aged over 65 years by 2050. A major current challenge is maintaining mobility and quality of life into old age. Impaired mobility is often a precursor of fu...

    Authors: Robin A McGregor, David Cameron-Smith and Sally D Poppitt

    Citation: Longevity & Healthspan 2014 3:9

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  3. Content type: Research

    Replicative senescence is preceded by loss of repeat sequences of DNA from the telomeres that eventually leads to telomere dysfunction, the accumulation of irreparable DNA double strand breaks and a DNA damage...

    Authors: Alice de Castro, Fay Minty, Eva Hattinger, Ronald Wolf and Eric Kenneth Parkinson

    Citation: Longevity & Healthspan 2014 3:8

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  4. Content type: Editorial

    The role of mitochondria in aging and disease remains contentious more than 40 years after the mitochondrial free radical theory of aging was first proposed. As part of a wider cross-journal series on contempo...

    Authors: Martin D Brand

    Citation: Longevity & Healthspan 2014 3:7

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  5. Content type: Review

    The free radical theory of aging proposes that reactive oxygen species (ROS)-induced accumulation of damage to cellular macromolecules is a primary driving force of aging and a major determinant of lifespan. A...

    Authors: Dao-Fu Dai, Ying Ann Chiao, David J Marcinek, Hazel H Szeto and Peter S Rabinovitch

    Citation: Longevity & Healthspan 2014 3:6

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  6. Content type: Research

    Insulin/IGF-1 signaling plays a central role in longevity across phylogeny. In C. elegans, the forkhead box O (FOXO) transcription factor, DAF-16, is the primary target of insulin/IGF-1 signaling, and multiple is...

    Authors: Ankita Bansal, Eun-Soo Kwon, Darryl Conte Jr, Haibo Liu, Michael J Gilchrist, Lesley T MacNeil and Heidi A Tissenbaum

    Citation: Longevity & Healthspan 2014 3:5

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  7. Content type: Review

    Since its inception more than four decades ago, the Mitochondrial Free Radical Theory of Aging (MFRTA) has served as a touchstone for research into the biology of aging. The MFRTA suggests that oxidative damag...

    Authors: Jeffrey A Stuart, Lucas A Maddalena, Max Merilovich and Ellen L Robb

    Citation: Longevity & Healthspan 2014 3:4

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  8. Content type: Research

    Osteoarthritis (OA) is the most common joint disorder in the world and represents the leading cause of pain and disability in the elderly population. Advancing age remains the single greatest risk factor for O...

    Authors: Daniel P Tonge, Ronald G Bardsley, Tim Parr, Rose A Maciewicz and Simon W Jones

    Citation: Longevity & Healthspan 2013 2:15

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  9. Content type: Research

    Life expectancy at birth in the first world has increased from 35 years at the beginning of the 20th century to more than 80 years now. The increase in life expectancy has resulted in an increase in age-relate...

    Authors: Rebeca Garcia-Valles, Mari Carmen Gomez-Cabrera, Leocadio Rodriguez-Mañas, Francisco J Garcia-Garcia, Ana Diaz, Inma Noguera, Gloria Olaso-Gonzalez and Jose Viña

    Citation: Longevity & Healthspan 2013 2:14

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  10. Content type: Review

    Aging-related loss of muscle mass, a biological process named sarcopenia, contributes to mobility impairment, falls, and physical frailty, resulting in an impaired quality of life in older people. In view of t...

    Authors: Gilles Gouspillou, Martin Picard, Richard Godin, Yan Burelle and Russell T Hepple

    Citation: Longevity & Healthspan 2013 2:13

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  11. Content type: Research

    The aim of the present study was to determine the influence of age and habitual activity level, at rest and following a single bout of high-intensity exercise, on the levels of three proteins poly(ADP-ribose) ...

    Authors: James N Cobley, George K Sakellariou, Scott Murray, Sarah Waldron, Warren Gregson, Jatin G Burniston, James P Morton, Lesley A Iwanejko and Graeme L Close

    Citation: Longevity & Healthspan 2013 2:11

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  12. Content type: Short Report

    Obesity is a health problem that is reaching epidemic proportions worldwide. We investigated the effects of a life-long high saturated fat and low carbohydrate (HF) diet on the body mass, glucose tolerance, co...

    Authors: Alexandre Pastoris Muller, Marcelo de Oliveira Dietrich, Adriano Martimbianco de Assis, Diogo Onofre Souza and Luis Valmor Portela

    Citation: Longevity & Healthspan 2013 2:10

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  13. Content type: Research

    C. elegans mitochondrial (Mit) mutants have disrupted mitochondrial electron transport chain function, yet, surprisingly, they are often long-lived, a property that has offered unique insights into the molecular ...

    Authors: Sara Maxwell, Joanne Harding, Charles Brabin, Peter J Appleford, Ruth Brown, Carol Delaney, Garry Brown and Alison Woollard

    Citation: Longevity & Healthspan 2013 2:9

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  14. Content type: Review

    Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.

    Authors: Daniel Baylis, David B Bartlett, Harnish P Patel and Helen C Roberts

    Citation: Longevity & Healthspan 2013 2:8

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  15. Content type: Meeting report

    The focus of the British Society for Research on Ageing (BSRA) annual scientific meeting 2012 was aging mechanisms and mitigants. The themes covered included epigenetics, stem cells and regeneration, aging pat...

    Authors: Hannah Greenwood and David B Bartlett

    Citation: Longevity & Healthspan 2013 2:6

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  16. Content type: Research

    This study was conducted to evaluate the effects of rhizome powder from the herb Rhodiola rosea, a traditional Western Ukraine medicinal adaptogen, on lifespan and age-related physiological functions of the fruit...

    Authors: Dmytro V Gospodaryov, Ihor S Yurkevych, Mahtab Jafari, Volodymyr I Lushchak and Oleh V Lushchak

    Citation: Longevity & Healthspan 2013 2:5

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    The Erratum to this article has been published in Longevity & Healthspan 2013 2:12

  17. Content type: Research

    Caloric restriction is known to extend the lifespan of all organisms in which it has been tested. Consequently, current research is investigating the role of various foods to improve health and lifespan. The r...

    Authors: Scott A Nankervis, Jenee M Mitchell, Fadi J Charchar, Maree A McGlynn and Paul A Lewandowski

    Citation: Longevity & Healthspan 2013 2:4

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  18. Content type: Research

    Alteration in the immune system is one of the most profound aspects of aging. Progressive changes in the number of B lymphocyte progenitors during aging have been reported but the underlying mechanisms are sti...

    Authors: Baohua Liu, Shuangcheng Zhou, Xinguang Liu, Keyuan Zhou, Fengju Zhang and Zhongjun Zhou

    Citation: Longevity & Healthspan 2013 2:1

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  19. Content type: Research

    The longevity of an organism is influenced by both genetic and environmental factors. With respect to genetic factors, a significant effort is being made to identify pharmacological agents that extend life spa...

    Authors: George L Sutphin, Emma Bishop, Melana E Yanos, Richard M Moller and Matt Kaeberlein

    Citation: Longevity & Healthspan 2012 1:9

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  20. Content type: Review

    Ageing impacts negatively on the development of the immune system and its ability to fight pathogens. Progressive changes in the T-cell and B-cell systems over the lifespan of individuals have a major impact o...

    Authors: Adriana Martorana, Matteo Bulati, Silvio Buffa, Mariavaleria Pellicanò, Calogero Caruso, Giuseppina Candore and Giuseppina Colonna-Romano

    Citation: Longevity & Healthspan 2012 1:8

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  21. Content type: Review

    The decreased efficiency of immune responses in older people is partly a consequence of alterations in T lymphocyte functions caused by modifications in the early events of signal transduction. Several alterat...

    Authors: Tamas Fulop, Aurélie Le Page, Hugo Garneau, Naheed Azimi, Sarra Baehl, Gilles Dupuis, Graham Pawelec and Anis Larbi

    Citation: Longevity & Healthspan 2012 1:6

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  22. Content type: Meeting report

    An international workshop was hosted by the University of Liverpool on 15–16 July 2011 to address at a basic level what is known about the fundamental mechanisms by which skeletal muscle mass and function are ...

    Authors: Malcolm J Jackson, Anne McArdle, Aphrodite Vasilaki and Anna Kayani

    Citation: Longevity & Healthspan 2012 1:5

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  23. Content type: Review

    The Free Radical or Oxidative Stress Theory of Aging is one of the most popular theories in aging research and has been extensively studied over the past several decades. However, recent evidence using transge...

    Authors: Lisa C Flores, Melanie Ortiz, Sara Dube, Gene B Hubbard, Shuko Lee, Adam Salmon, Yiqiang Zhang and Yuji Ikeno

    Citation: Longevity & Healthspan 2012 1:4

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  24. Content type: Research

    Chronic dietary restriction (DR) has been shown to have beneficial effects on glucose homeostasis and insulin sensitivity. These factors show rapid and robust improvements when rodents were crossed over from an a...

    Authors: Kerry M Cameron, Satomi Miwa, Cornelia Walker and Thomas von Zglinicki

    Citation: Longevity & Healthspan 2012 1:3

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